Science Translational Medicine published the study demonstrating the first evidence of the assay in kidney transplant from NephroSant, a Kidney Health spinout from UCSF, led by Dr. Minnie Sarwal
NephroSant, a startup company that is focused on redefining kidney health, today announced the landmark publication showing high accuracy for a urine-based assay for the surveillance of kidney transplant patients to identify rejection.
The study was published in Science Translational Medicine and demonstrates the assay, called QiSant, can successfully identify both types of rejection - t-cell mediated rejection (TCMR) and antibody mediated rejection (ABMR) - in over 600 patients with accuracy over 95%. The study also showed the ability of QiSant to predict rejection episodes up to 200 days before a biopsy-confirmed rejection. Finally, the test showed the ability to identify rejection in adult and pediatric populations, as well as re-transplants.
"The ability to detect rejection with high sensitivity and specificity from urine has the ability to transform the monitoring of kidney transplant patients," said Dr. Minnie Sarwal, UCSF Professor in Residence in Surgery and Medicine and founder of NephroSant. "Up to 20% of kidney transplants each year are re-transplants. This underscores the need to maximize the success of future transplants by identifying rejection risk and manage patients in a more proactive way," she added.
NephroSant has already published five scientific papers looking at the performance of the assay in other areas of kidney health, most notably in identifying Chronic Kidney Disease and recurrence of kidney stones.
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